Project contract finalization
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MSA is signed between the CRO and Sponsor. Project contracts are signed for each study. This project contract is sometimes signed after the study protocol is signed by PI (of CRO) and Sponsor (MSA continues to be valid). Is this acceptable?
No idea. Have a look at the MHRA GCP Guide (2012) which has a good section on contracts. My approach would be that it is important that the agreements and protocol are signed before any project work at all is started. So that anything that the site does has already been agreed and signed before it is commenced.