Trev Simmons (Chair DIGIT)
As a powerful collaboration tool, SharePoint is capable with the appropriate configuration of being an eTMF. It would need to be subject to validation as would any GxP system, and as a powerful tool available in Cloud or In-house solutions the Validation will depend on your set up and the functionality you want to implement.
SharePoint *can* be configured for Version control as a document management system, automated workflows for document creation, review, approval and distribution, and with Webparts and add-ons you can add functionality to further support document control and integrity mechanisms.
SharePoint security can integrate with your network security including Group/Role based security, However it is weak on meeting Electronic Signature Requirements out of the box, however add-ins are available to address this.
So to answer the question, Yes it can be subject to Validation and implementation of 21 CFR Part 11 and Annex 11 for audit trails, disaster recovery and record retention etc.
The full answer is a matter of consultancy of a Validation expert and a SharePoint Developer, as it may be more cost effective to buy an alternative solution, or find a vendor who offers a SharePoint eTMF solution rather than invest in your own customised SharePoint solution.