When no SDV is performed at the COV (which is usually the case if it is not a combined interim-close-out-visit) then a remote close-out should not be a big deal. The risk-based approach and the EMA/MHRA/FDA/... guidances have already been mentioned. >> Just do a pragmatic approach and ask: what would you do at the on-site COV? Then assess how you could do these tasks remotely /on-line. For example reviewing the site delegation/signature log can be done via camera or you ask the site to provide you with this document prior to the visit. Inform the site to provide you with the original or copy (as per your SOPs, but why should sites archive copies?) after the visit. Inform the site on archiving requirements, send the respective labels to the site. >> If you need to close the pharmacy and drug account needs to be finally performed: ask the pharmacy whether they could send you a photo of the remaining IMP (if any) and let them send you the drug accountability logs (before the COV and the final logs after the COV). >> In short: ask what you need prior to the COV, what you will do during the COV remotely and what you need after the COV. >> Remember to document everything as stated in the respective guidances.